Natural moisturizing factor (NMF) in the stratum corneum has a high moisture retaining efficacy, and plays a major role in the skin barrier function.
Pyrrolidone carboxylic acid (PCA) is one of the major NMFs found in human skin.
Aquatide, PCA-mimetic peptide, increases moisturisation, activates autophagy, reduces Trans Epidermal Water Loss (TEWL) and improves the skin barrier function.
Autophagy and AQUATIDE 5000
Autophagy is the natural destructive mechanism that allows the orderly degradation and recycling of cellular components.
Increased autophagy delays aging and extends longevity.
Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)- dependent deacetylase functioning in the regulation of metabolism, cell survival and organismal lifespan. Active SIRT1 regulates the autophagy during cell stress, including calorie restriction, endoplasmic reticulum (ER) stress and oxidative stress.
AQUATIDE 5000 (INCI name: Hexacarboxymethyldipeptide-12), the first known peptide-derived SIRT1 activator, activates SIRT1 by direct interaction. Through this interaction AQUATIDE 5000 increases a deacetylation of SIRT1 target protein FoxO1, resulting in the cell protective autophagy.
AQUATIDE 5000 treatment increases LC3 puncta forma- tion (green dots) similar as rapamycin.
Increases Water Retaining Activity
AQUATIDE 5000 shows water retaining activity and inc-reases skin hydration.
Reduces TEWL(TransEpidermal Water Loss)
AQUATIDE 5000 enhances the skin barrier function and prevents water loss.
Improves Skin Barrier Function and Anti-ACNE Efficacy
Sixteen volunteers were applied with 1% AQUATIDE 5000 and 0.5% salicylic acid formulation for 4 weeks. Skin conditions were evaluated by dermatologist.
AQUATIDE 5000 has a strong anti-inflammatory activity, and reduces average 65% of ACNE symptoms.
Increases ceramide contents
AQUATIDE 5000 increases synthesis of long and very long chain ceramides in the skin