Excessive sebum formation, follicular epithelial barrier
dysfunction, and inflammatory responses induced by Cutibacterium acne are major triggering and aggravating factors for acne.
While conventional anti-acne ingredients addressing sebum formation usually dry up the skin surface, resulting in skin dryness, Sebodulin restores healthy hydrolipidic film by activation of autophagy in sebocytes, the sebum making cells in skin.
Sebodulin also help to alleviate the inflammatory responses by C. acne and to improve the skin barrier function.
New Autophagy Activator
Sebodulin activates the autophagy in cultured immortalized sebocytes(left) and reconstituted skin model(right).
Reduction of Sebum Formation
Sebodulin reduces lipid synthesis in cultured human sebocytes
In vitro Anti-inflammatory Activity
Sebodulin inhibits pro-inflammatory cytokine IL-8 secretion in skin keratinocytes(left) and immune cells(right) treated with cell free extract of C. acne.
Reduction of Inflammatory Response by C. acne
Sebodulin preventes reduction of autophagy and increase of inflammation caused by topical application of C. acne in reconstituted skin model
Sebodulin contained product reduces whitehead by 30% than before (by investigator assessment).
Skin surface lipids
Sebodulin contained product reduces quantity of skin surface lipid (by sebumeter).