Biotide2000 is a conjugate of hexapeptide-2 and biotin.
Hexapeptide-2 plays an important role in increasing muscle mass, and rejuvenating connective tissues by stimulating the growth hormone secretion.
Biotin, known as vitamin B7, also plays an important role in the epidermal metabolism and turn over to keep healthy skin conditions.
Aged dermis contains low quantity of collagen, which weakens dermal strength and appears fine wrinkle on all face.
Biotide2000 directly stimulates the collagen production in the fibroblast cells, and also increases the mass of healthy fibroblasts consisting dermis layer of the skin.
Increases collagen expression in 3D skin model
Biotide2000 increases collagen expression (Masson’s Trichrome staining and ELISA) and enlarges dermis layer
Induces expression of cell communicating proteins
Biotide2000 increases expression of Collagen-17, Laminin-5 and Integrin-α6
Action mechanism of Biotide2000
Biotide2000 stimulates not only collagen gene expressionin fibroblast cells, but also keratinocyte cells to secret paracrine factors(FGF2, FGF5 and Interleukins), which activate dermal fibroblast cells to synthesize collagen actively.
Reduces Fine wrinkle
The fine wrinkles reduced after 4-5 weeks of Biotide2000 application, and its reduction is significant after 9 weeks of application.