Thioredoxin(TRX) is known to control REDOX (Oxidation-Reduction) reactions and activate not only all the anti-oxidation system but also the bio-stress defense system against inflammation and immunological reaction of living cells.
Japanese Sake is well known for the benefit on skin as their hands of Sake artisan are white, healthy and beautiful. Bioredoxyl is an extract with high content of thioredoxin(TRX), which is obtained during traditional sake fermentation using Koji yeast. TRX has been reported to have powerful anti-oxidant, anti-stress and anti-inflammation activities, resulting in anti-ageing, wrinkle and redness reduction, improvement of atopic dermatitis symptoms.
Skin toning lotion containing 0.2% Bioredoxyl was applied after UV radiation on the inner side of forearms 2 times/day for 14 days to 11 volunteers(women of 31-49 years old). L value was measured by a spectro-colorimeter CM-2600d. Reduction of redness induced by UV radiation was observed immediately after UV irradiation but redness was almost eliminated within 2 weeks at the spot where Bioredoxyl was applied (p < 0.05).
0.2% Bioredoxyl containing formulation was applied twice a day for 4 weeks, and melanin and hemoglobin level, which are the indicators of skin toning, were significantly decreased when measured using VISIA Evolution.
0.2% Bioredoxyl containing formulation was applied twice a day for 4 weeks, and the leangth of wrinkles were significantly reduced when measured using reflective replica analysis system ASA-03RXD
0.2% Bioredoxyl containing formulation was applied for 4 weeks to adults (men and women of 29-55 years old) with atopic dermatitis, and the symptoms were improved when measured using the moisture checker MY-808S.
0.2% Bioredoxyl containing formulation was applied for 4 weeks to infants and children (men and women of 0-8 years old) with atopic dermatitis, and the symptoms were improved when measured using the moisture checker MY-808S.
Moderate hyper immune-response, anti-oxidation, anti-inflammation
Rice Ferment Filtrate(SAKE) [TRX content: over 1,000ppm]