Wasabi is the typical herbal medicinal spice originated in Japan known for its anti-bacterial and anti-toxin activities. These activities are due to a special flanovoid called isosaponarin identified from the wasabi flavones extract.
Wasabi flavones not only facilitates intracellular collagen biosynthesis, but also helps collagens to form triple helix structure, which is essential for wrinkle reduction and enhanced elasticity of the skin.
When 0.5% wasabi flavones containing formulation was applied for 4 weeks, significant improvements in both elasticity and texture were observed, when measured using a Triplesence.
When 0.1% wasabi flavones containing formulation was applied for 12 weeks, significant decrease in the areas of wrinkle was observed, when measured using a reflective replica analysis system ASA-03RXD.
Wasabi flavones increased the mRNA transcription level of TGFß, which induces collagen biosynthesis. Wasabi flavones also increased translation level of proryl-4-hydroxylase, the protein responsible for pro-collagen transcription and collagen maturation. Consequently, it significantly increased the expression of collagen-1 proteins.
Maturation of collagen, anti-wrinkle, anti-aging
1,3-Butylene glycol(98.8%), Wasabia Japonica Leaf Extract(1.2%)